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Biotech Stock Spikes On Promising First In-Human CRISPR Gene-Editing Drug

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Shares of Crispr Therapeutics (CRSP) jumped Tuesday after the biotech company’s gene-editing approach showed early promise. During the regular session on the stock market today, Crispr stock popped 17%, to 68.46, in above-average volume. At nine months following infusion, the beta thalassemia patient didn’t need a blood transfusion. Four months after treatment, the sickle cell patient didn’t experience any vaso-occlusive crises, a painful complication of the disease.  “While still very early, the results provide the first suggestion of curative potential for this cutting-edge technology in such genetic diseases,” RBC Capital Markets analyst Brian Abrahams said in a report to clients. CRISPR Gene-Editing Drug Shows Promise Prior to receiving the CRISPR gene-editing treatment, the patient with beta thalassemia needed 16.5 blood transfusions each year, at an annualized...
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Doctors safely used CRISPR technology on 3 cancer patients in the US for first time

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The first attempt in the United States to use a gene editing tool called CRISPR against cancer seems safe in three patients who’ve had it so far,  doctors reported Wednesday. The doctors were able to take immune system cells from the patients’ blood and alter them genetically to help them recognize and fight cancer, with minimal and manageable side effects, the AP reports. The treatment deletes three genes that might have been hindering these cells’ ability to attack the disease, as well as adds a new, fourth feature to help them do the job. “It’s the most complicated genetic, cellular engineering that’s been attempted so far,” said study leader Dr. Edward Stadtmauer of the University of Pennsylvania. Two of the patients have...
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CRISPR Gene-Editing May Offer Path To Cure For HIV, First Published Report Shows

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There’s been a lot of excitement lately that the powerful gene-editing technique CRISPR could offer a new way to treat health problems ranging from cancer to blindness. But there hasn’t been much direct scientific evidence in actual patients about whether it might work or would be safe — until now. Chinese scientists have published the first report in a scientific journal of an attempt to use CRISPR-edited cells in a patient–a 27-year-old man who is HIV-positive. While the treatment did not rid the man of the AIDS virus, the researchers and others are calling the report promising. That’s because it indicates that so far the gene-editing technique seems to safely and effectively make the precise DNA change intended. “It is a...
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Another miracle: CRISPR is gene-editing pain away

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Scientists say is a step toward a CRISPR gene therapy that could block severe pain caused by diabetes, cancer, or car accidents without the addictive effects of opioids. The street performer was only 10 years old. He put knives through his arms and walked on hot embers. By 14 he was dead. Someone dared him to jump from a roof. He did it, knowing it wouldn’t hurt. The case of the Pakistani boy with a rare genetic disorder was described in 2006. He could feel warmth and cold and the texture of objects. But he never felt pain. Now scientists have paired the discovery with the gene-editing tool CRISPR, in what they say is a step toward a gene therapy that...
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CRISPR enters its first human clinical trials. The gene editor targets cancer, blood disorders and blindness.

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Scientists will soon wield the molecular scissors CRISPR/Cas9 in the human body. Some people with a form of inherited blindness will have the gene editor injected into their eyes, where researchers hope it will snip out a mutation. Since its debut in 2012, CRISPR gene editing has held the promise of curing most of the over 6,000 known genetic diseases. Now it’s being put to the test. In the first spate of clinical trials, scientists are using CRISPR/Cas9 to combat cancer and blood disorders in people. In these tests, researchers remove some of a person’s cells, edit the DNA and then inject the cells back in, now hopefully armed to fight disease. Researchers are also set to see how CRISPR/Cas9...
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CRISPR breakthrough allows scientists to edit multiple genes simultaneously

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Genes and proteins in cells interact in many different ways. Each dot represents a gene; the lines are their interactions. For the first time, the new method uses biotechnology to influence entire gene networks in a single step(Credit: ETH Zurich / Carlo Cosimo Campa) We’ve seen a number of recent improvements to the CRISPR gene editing method, from enhanced precision to novel techniques to block the process. But despite all these innovations, the technique is generally only able to modify one single gene at a time. An incredible new breakthrough from scientists at ETH Zurich has, for the first time, demonstrated a new CRISPR method that can modify dozens of genes simultaneously, allowing for more large-scale cell reprogramming. In a recently published...
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The Future of Medicine Land Within 5 – 10 Years, Crispr Inventor Says

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A pioneer of the Crispr gene-editing technology that’s taken Wall Street by storm says the field is probably five to 10 years away from having an approved therapy for patients. Biochemist Jennifer Doudna, who runs the Doudna Lab at the University of California at Berkeley, says major questions remain about the safety and effectiveness of experimental therapies that aim to disrupt or repair defective genes. But she’s optimistic about their prospects. “Can we today edit the DNA in human cells? Yes. Can we do it accurately? Yes. That’s absolutely being done in many labs around the world now,” Doudna said in an interview on the sidelines of a gene-editing summit at the Cold Spring Harbor Laboratory in New York. “But the challenge is how...
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CRISPR Technology Market to Reach $10.55 Billion by 2027, Reports BIS Research

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According to a new market intelligence report by BIS Research, titled “Global CRISPR Technology Market – Analysis and Forecast, 2018-2027“, the global CRISPR technology market is anticipated to grow to $10.55 billion by 2027. The global CRISPR technology market is projected to grow at a CAGR of 34.46% between the years 2018 and 2027, aided by the remarkable growth in the fields of therapeutic & drug discovery, biological research, and agricultural biotech.  Genetic diseases approximately constitute for 25% of global economic burden for disease. The rising prevalence of several genetic diseases has significantly elevated the requirement for improved gene targeting methods with greater efficiency. The recent advancements in sequencing and genomic technologies has paved pathway for the development of efficient genome editing...
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What is CRISPR gene editing, and how does it work?

You’ve probably read stories about new research using the gene editing technique CRISPR, also called CRISPR/Cas9. The scientific world is captivated by this revolutionary technology, since it is easier, cheaper and more efficient than previous strategies for modifying DNA. The term CRISPR/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated protein 9. The names reflect important features identified during its discovery, but don’t tell us much about how it works, as they were coined before anyone understood what it was. What does CRISPR/Cas9 do? CRISPR/Cas9 is a system found in bacteria and involved in immune defence. Bacteria use CRISPR/Cas9 to cut up the DNA of invading bacterial viruses that might otherwise kill them. Today we’ve adapted this molecular machinery for an entirely different purpose – to change...
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CRISPR gene-editing tested in a person for the first time

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A Chinese group has become the first to inject a person with cells that contain genes edited using the revolutionary CRISPR–Cas9 technique. On 28 October, a team led by oncologist Lu You at Sichuan University in Chengdu delivered the modified cells into a patient with aggressive lung cancer as part of a clinical trial at the West China Hospital, also in Chengdu. Earlier clinical trials using cells edited with a different technique have excited clinicians. The introduction of CRISPR, which is simpler and more efficient than other techniques, will probably accelerate the race to get gene-edited cells into the clinic across the world, says Carl June, who specializes in immunotherapy at the University of Pennsylvania in Philadelphia and led one...
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