News | CRISPR, crispr genome editing system - Part 2

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Cutting Out Cancer: CRISPR Gene Editing Could Make Cancer Mutations Inactive

A group of researchers from Dresden’s National Center for Tumor Disease (NCT), the Medical Faculty of the Technische Universität (TU) Dresden, and the German Consortium for Translational Cancer Research (DKTK), have found a way to use CRISPR-Cas9 to identify and cut out the particular cancer genes that advance mutations. “Mutations in cancer cells are identified at increasing speed through next generation sequencing, but we mostly do not know, which of these mutations are actually driving the disease and which ones are rather benign,” leading researcher Frank Buchholz said in a journal article. Of the more than 500,000 identified cancer mutations, the researchers were able to confirm that more than 80% can be cleaved using CRISPR-Cas9 scissors. DRIVER AND PASSENGER   National...
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CRISPR used to make a tumour shrink itself

Scientists have used gene editing to reprogramme a signal that normally promotes tumour growth into one that shrinks it instead. In a study published in Nature Methods, a team from the First Affiliated Hospital of Shenzhen University, China, showed how they could stop the growth of cancer in cells by modifying part of the CRISPR–Cas9 system. When mice carrying these modified genes were tested, scientists found their tumours were far smaller than those seen in control animals. CRISPR-Cas9 is a gene editing platform that is currently being looked at as a means of providing treatments for diseases by targeting cells. Cas9 is an enzyme that cuts a double DNA strand at a point, while CRISPR is a chemical messenger. The...
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CRISPR: A Billion-Dollar Pie

CRISPR sits in the middle of a costly patent brawl. That hasn’t stopped scientists and venture capitalists from betting on who will win. Business is moving fast with licenses being sold, awaiting the USPTO’s decision in November which may declare a winner on the patent. When it comes to pharmaceuticals, patents are licensed and traded in the amount of millions of dollars funneled through a 14 to 20-year timer. While the stakes are high, CRISPR/Cas9 is not the only gene editing technology out there. It was however, the first gene editing technology to be discovered in ancient bacteria, channeling new interest with the hope to discover an unclaimed and more effective gene editing technique. Who’s Who in the CRISPR Patent Brawl...
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Scientists shocked by major CRISPR breakthrough

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Genetic engineering has popped up in the headlines again after a breakthrough study pushed the CRISPR-Cas9 editing technique to a new level of precision. According to a report from Nature, the technique used for cutting and pasting genes has now been adapted to work for cutting RNA. The breakthrough could give researchers an entire new set of tools for studying and attempting to treat diseases. The study was published by a team led by Feng Zhang from the Broad Institute. Researchers used CRISPR, which stands for “clustered regularly interspaced short palindromic repeats,” to begin splicing and rearranging RNA strands. Published in the journal Science, the findings could lead to techniques that could significantly reduce the burden of a number of...
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USDA announces it will stop regulating all GMO crops altered with CRISPR gene editing technique

As reported by Business Insider, the U.S. Department of Agriculture released a letter to the public last week confirming that the agency does not plan to regulate a mushroom thathas been genetically modified so that it won’t turn brown. The letter was in response to an inquiry from mushroom developer Dr. Yinong Yang, of the College of Agricultural Services at Penn State University, about whether a division of the USDA would be seeking to regulate the mushroom. This decision, wherever it ultimately came from, is in contrast to the USDA’s previous approach with GMOs, which are regulated by the department’s Animal and Plant Health Inspection Service (APHIS). That division supposedly monitors new genetically modified foods that “may pose a risk...
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CRISPR Treatment for HIV reportedly three years away

An end to HIV and Supports reportedly could be simply a couple of years away after researchers have had the opportunity to successfully snip away the disease from infected skin cells and prevent the condition from returning.  Researchers at the Lewis Katz College of Medication at Temple University or college are confident that next three years they’ll be able to start out human trials, the united kingdom Daily Telegraph reported. American researchers have previously shown that it’s possible to edit genes to slice the virus from DNA cells entirely. British experts assume that this treatment, which includes only been tried in labs, allows your body to “cure itself from the within effectively,” the newspaper reported. People immune cells which were...
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CRISPR could eventually allow us to treat HIV, cancer, autism

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Researchers have managed to devise a new method using gene-editing tool CRISPR-Cas9 that can track movement of RNA in living cells thereby enabling them to study a wide range of disease-related RNA processes. The study, published in Cell, paves way for even greater promise of finding a cure for deadly diseases like HIV and cancer. The work, according to researchers at University of California, San Diego, is just the tip of the iceberg and holds immense potential as it opens a whole new door for treating diseases by correcting disease-causing RNA behaviors – something that wasn’t possible until now considering that CRISPR-Cas9 only targeted DNA. Researchers acknowledge that there are methods that enable them to recognize and track RNA, but...
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Two New Techniques May Enhance Genetic Engineering With CRISPR

Scientists have discovered two new methods capable of enhancing the efficiency of genetic engineering, and these new gene modification techniques could be huge when it comes to future research studies. The two new methods are called the IsODN (long single-stranded oligodeoxynucleotide) and 2H2OP (two-hit two-oligo with plasmid) and are used in conjunction with CRISPR-Cas systems and ssODN (single-stranded oligodeoxynucleotide). CRISPR-Cas systems, in particular, have greatly helped with gene modification in mice and rats. This system involves using Cas9 messenger RNA and gRNA. The gRNA recognizes targeted DNA, and then Cas9 cuts the targeting site. This, effectively, leaves a hole that is then repaired by non-homologous end joining; this causes DNA mutations, resulting in gene knock-out. Similar to this system is...
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CRISPR Critters: Regulators and the New Gene Revolution in Agriculture

It’s CRISPR’s world, and we’re just living in it. The gene-editing technology, which has been likened to a genetic word processor, allows researchers to make specific changes ranging from tweaking a single DNA base pair to revising whole paragraphs of genetic information. Most of CRISPR’s media attention has focused on the vast improvements it could bring to medicine, such as fixing genetic diseases, curing cancer, speeding up vaccine development, andovercoming antibiotic resistance in disease-causing microbes. Less widely reported, but no less momentous, are the dramatic transformations that CRISPR will bring to nearly all aspects of farming. All that is needed for this new green revolution to take off is for regulators to get out of the way. Thanks to entirely...
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