News | CRISPR, crispr genome editing system - Part 3

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CRISPR Treatment for HIV reportedly three years away

An end to HIV and Supports reportedly could be simply a couple of years away after researchers have had the opportunity to successfully snip away the disease from infected skin cells and prevent the condition from returning.  Researchers at the Lewis Katz College of Medication at Temple University or college are confident that next three years they’ll be able to start out human trials, the united kingdom Daily Telegraph reported. American researchers have previously shown that it’s possible to edit genes to slice the virus from DNA cells entirely. British experts assume that this treatment, which includes only been tried in labs, allows your body to “cure itself from the within effectively,” the newspaper reported. People immune cells which were...
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CRISPR could eventually allow us to treat HIV, cancer, autism

White blood cells
Researchers have managed to devise a new method using gene-editing tool CRISPR-Cas9 that can track movement of RNA in living cells thereby enabling them to study a wide range of disease-related RNA processes. The study, published in Cell, paves way for even greater promise of finding a cure for deadly diseases like HIV and cancer. The work, according to researchers at University of California, San Diego, is just the tip of the iceberg and holds immense potential as it opens a whole new door for treating diseases by correcting disease-causing RNA behaviors – something that wasn’t possible until now considering that CRISPR-Cas9 only targeted DNA. Researchers acknowledge that there are methods that enable them to recognize and track RNA, but...
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Two New Techniques May Enhance Genetic Engineering With CRISPR

Scientists have discovered two new methods capable of enhancing the efficiency of genetic engineering, and these new gene modification techniques could be huge when it comes to future research studies. The two new methods are called the IsODN (long single-stranded oligodeoxynucleotide) and 2H2OP (two-hit two-oligo with plasmid) and are used in conjunction with CRISPR-Cas systems and ssODN (single-stranded oligodeoxynucleotide). CRISPR-Cas systems, in particular, have greatly helped with gene modification in mice and rats. This system involves using Cas9 messenger RNA and gRNA. The gRNA recognizes targeted DNA, and then Cas9 cuts the targeting site. This, effectively, leaves a hole that is then repaired by non-homologous end joining; this causes DNA mutations, resulting in gene knock-out. Similar to this system is...
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CRISPR Critters: Regulators and the New Gene Revolution in Agriculture

It’s CRISPR’s world, and we’re just living in it. The gene-editing technology, which has been likened to a genetic word processor, allows researchers to make specific changes ranging from tweaking a single DNA base pair to revising whole paragraphs of genetic information. Most of CRISPR’s media attention has focused on the vast improvements it could bring to medicine, such as fixing genetic diseases, curing cancer, speeding up vaccine development, andovercoming antibiotic resistance in disease-causing microbes. Less widely reported, but no less momentous, are the dramatic transformations that CRISPR will bring to nearly all aspects of farming. All that is needed for this new green revolution to take off is for regulators to get out of the way. Thanks to entirely...
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Improved CRISPR System Reads Induced Pluripotent Stem Cell Genome For the First Time

With an enhanced form of the CRISPR-Cas9 system, scientists were able to read the genome of induced pluripotent stem cells (iPSCs) for the first time. The new system provides a more temporary gene modification that will be extremely useful for scientists using this method to conduct therapeutic gene editing techniques. The new study builds off of a 2013 method developed by Stanly Qi, PhD, who is also a co-author on the current paper. Qi designed CRISPR interference (CRISPRi), a system with the ability to “inactivate genes in IPSCs and heart cells created from iPSCs.” CRISPRi improves the original system because genes can be silenced or turned off “more precisely and efficiently.” Plus, CRISPRi offers additional beneficial characteristics like deletion flexibility...
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CRISPR Design Tools for Genome Editing: the full list with description

crispr tools target
In just four years, CRISPR has revolutionized approaches to genome editing. Inexpensive to build and easy to use, CRISPR (Clustered, Regularly Interspaced. Short Palindromic Repeats) has gained worldwide attention for its ability to target specific locations in the genetic code of any organism with just two elements – guide RNA and an enzyme called Cas9. CRISPR was originally discovered as a genetic phenomenon in archaea and certain bacteria – an immune response that could be adapted for purposes of modifying the genes of higher organisms. Applications of crispr system design include genetic moderation of crops, gene therapies for diseases such as cancer, and synthesizing drug-producing microbes. CRISPR’s applications may be even more far-reaching in the future – but some fine-tuning...
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How the US CRISPR patent probe will play out

award crispr
There is no shortage of optimism about the scientific potential of CRISPR–Cas9, a technique that can precisely alter the genomes of everything from wheat to elephants. But there is a great deal of confusion over who will benefit financially from its use. On 10 March, the US Patent and Trademark Office (USPTO) will begin an investigation into who deserves the patent on using CRISPR–Cas9 to edit genes. This ‘patent interference’ could determine who profits from CRISPR in coming years. Already, companies have sprung up to take advantage of the technique in agriculture, industrial biotechnology and the treatment of human diseases. One firm, Editas Medicine in Cambridge, Massachusetts, raised US$94 million when it went public on 2 February, even though it does not...
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Researchers enhance CRISPR gene editing technology

Scientists have developed a process that improves the efficiency of CRISPR, an up-and-coming technology used to edit DNA. “Scientists all over the world are using CRISPR right now in their studies, but the technology is not as functional as it could be,” says Haoquan Wu, Ph.D., who enhanced the process and is a biomedical scientist at Texas Tech University Health Sciences Center El Paso (TTUHSC El Paso). CRISPR is a groundbreaking technology that allows scientists to modify genes. Two key components make CRISPR’s DNA editing ability possible. The first is Cas9, an enzyme capable of cutting DNA. The second component is single guide RNA, which directs Cas9 on exactly which portion of a DNA strain to snip to deactivate the...
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Bayer and Baxalta Battle for Gene Editing Domination With Billions of Dollars at Stake

The announcement comes hot on the heels of a now-$335 million deal between aspirin mainstay Bayer AG and gene editing startup CRISPR Therapeutics to create commercial gene therapies to treat congenital heart disease, blindness and blood disorders. We are very impressed by the scientific team of CRISPR Therapeutics as they have built the most promising gene-editing technology on the market, Dr. Axel Bouchon, head of the Bayer LifeScience Center, said in a press release. This is perfectly suited to fully leverage Bayer’s expertise in protein engineering and knowledge in the targeted disease areas of this [joint venture]. While the technologies CRISPR Therapeutics and Precision Bio use are different – CRISPR Therapeutics uses CRISPR/Cas9, Precision Bio has a proprietary method called...
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Software Helps Gene Editing Tool CRISPR Live Up to Its Hype

New algorithms make CRISPR as easy as point-and-click Biotechnologists are jumping at the chance to use the revolutionary gene-editing tool known as CRISPR. The molecular gadget can be programmed to accurately tweak the DNA of any organism, but scientists need software algorithms to hasten the programming process. Dozens of teams are developing such software, and each faces the task of keeping up with rapidly evolving science and an increasingly crowded field. CRISPR—short for Clustered, Regularly Interspaced, Short Palindromic Repeats—is a genetic phenomenon found in microbes that scientists adapted to disable a gene or add DNA at precise locations in the genetic code. CRISPR isn’t the first gene-editing tool on the block, but it is by far the simplest and cheapest,...
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