News | CRISPR, crispr genome editing system - Part 5

Home » Archive by category "News" (Page 5)

Intellia Therapeutics Launches New Division to Accelerate Ex Vivo Programs with CRISPR/Cas9

photo2
Intellia Therapeutics has launched a new division, eXtellia Therapeutics, with the intent of focusing resources and research on ex vivo applications of the novel technology, CRISPR/Cas9. As in vivo and ex vivo programs require different competencies in research, manufacturing and commercialization, eXtellia Therapeutics is being launched to accelerate Intellia’s efforts in areas of significant unmet medical need – immuno-oncology, autoimmune and inflammatory diseases – using an ex vivo approach. Intellia will continue its in vivo programs and strategy through a dedicated scientific team. “We are excited to announce the establishment of eXtellia, increasing our footprint in ex vivo gene editing for oncology and autoimmune diseases,” said Nessan Bermingham, Ph.D., Chief Executive Officer and Founder, Intellia Therapeutics. “eXtellia enables us to...
Read More..

U.K. researcher details proposal for CRISPR editing of human embryos

crispr-lab
LONDON—The hottest technique in gene editing, called CRISPR, could soon be used to study human embryos. On 14 January, a regulatory committee in the United Kingdom will evaluate a request to knock out development genes in day-old embryos. In a press conference today, Kathy Niakan, a researcher at the Francis Crick Institute in London, discussed the rationale behind her proposed project and the hope that this line of inquiry might one day improve treatments for infertility. Niakan studies how the single cell of a fertilized egg turns into a blastocyst, the approximately 5-day-old structure that subsequently implants in the mother’s uterus. The blastocyst contains several types of cells. Those destined to become the fetus are called epiblast progenitor cells. They...
Read More..

The CRISPR tool is already so crucial … that it was nominated for Word Of The Year – Washington Post

award crispr1
A futuristic gene-editing technology holds almost fantastical promise to turn biologists’ wildest dreams into reality. The technology called CRISPR could one day be used to delete the HIV virus from patients’ cells, create a limitless supply of organs for transplant and produce better crops. Already, it’s being used in laboratories across the world. This week, the fierce battle over who invented it officially kicked off, with hundreds of millions of dollars on the line. A patent judge rang the opening bell Monday, pitching two heavyweight research institutions perched on opposite coasts against each other: the University of California Berkeley vs. the MIT- and Harvard-affiliated Broad Institute in Cambridge. The judge’s declaration of “interference,” a technical term meaning that a conflict exists between a patent application and another...
Read More..

‘Crispr’ gene editing technique may treat inherited blindness

crispr_core
New York: A new gene editing technique which was hailed as the breakthrough of 2015 by Science Magazine has been found effective in preventing retinal degeneration in a type of inherited blindness, a study says. The researchers focused on inherited retinitis pigmentosa, a degenerative eye disease with no known cure that can lead to blindness. They used a technique known as Crispr-Cas9, to remove a genetic mutation that causes the blindness disease. Although the study involved rats, it is an important milestone because of its potential implications for humans. “Our data show that with further development, it may be possible to use this gene-editing technique to treat inherited retinitis pigmentosa in patients,” said senior author of the study Shaomei Wang...
Read More..

Finding Enhancers with CRISPR

crispr image5
While several groups are working to apply the CRISPR/Cas9 system for clinical purposes, some are using the tool to address fundamental questions about biology. Reuven Agami, a professor of genetics at the Netherlands Cancer Institute in Amsterdam, and his colleagues recently applied CRISPR to search for regulatory enhancer elements throughout the genome. They targeted the Cas9 nuclease to previously identified enhancer elements—transcription factor-binding DNA sequences that distally regulate gene expression—of two transcription factors: p53, and estrogen receptor alpha (ERα), which are both frequently mutated and deregulated in cancer. The team’s findings, published today (January 11) in Nature Biotechnology,highlight key enhancer sequences of these two proteins, and demonstrate the utility of CRISPR for the systematic study of noncoding DNA sequences. Two...
Read More..

We routinely say ‘Crispr’ing’ when we talk about changing specific genes – Paul Knoepfler, a biologist at the University of California

crispr_systme_try
A new gene-editing technology has been relentlessly hyped over the past year, and it goes by a catchy if rather incongruous acronym: Crispr. Hailed as the breakthrough of 2015 by Science Magazine, Crispr could potentially help eradicate diseases like malaria and, more controversially, could be used to modify the DNA of human embryos. But it’s safe to say that Crispr would not be grabbing the headlines if it were known by its full name: “clustered regularly-interspaced short palindromic repeats.” The acronym emerged out of email exchanges in 2001 between two microbiologists: Francisco Mojica of the University of Alicante in Spain, and Ruud Jansen, then at Utrecht University in the Netherlands. A team led by Dr. Jansen is believed to be...
Read More..

Top 10 CRISPR predictions for New Year 2016

prediction
CRISPR is the hottest new biotechnology and the top development of 2015 according to Science Magazine. What will the new year of 2016 bring on the CRISPR front? It’s clear there will be more meetings on CRISPR ethics and policy (heck, we are having one right here at UC Davis on May 26), but what else is coming? Below are my top 10 CRISPR predictions for the new year in no particular order. What are your CRISPR predictions? For more on my thinking on CRISPR and the future, also please take a look at my new book, GMO Sapiens and for the extreme case of what could go wrong see my TED talk. The CRISPR predictions. The Noah’s arc of CRISPR-y critters continues...
Read More..

Bayer, CRISPR Therapeutics Launch JV to Develop CRISPR/Cas9 Treatments

49266_S15
NEW YORK (GenomeWeb) – Switzerland’s CRISPR Therapeutics and Germany’s Bayer today announced a yet unnamed joint venture to develop ways to deliver CRISPR/Cas9 genome editing in a clinical setting. The deal brings together Bayer’s experience in protein engineering and knowledge of human diseases with CRISPR Therapeutics’ CRISPR/Cas9 intellectual property and genome editing expertise, the firms said in a statement. Under the terms of the agreement, the partners will launch the joint venture to find, develop, and commercialize new therapies for blood disorders, blindness, and congenital heart disease. Bayer will provide at least $300 million over five years for R&D expenses as well as acquire a minority stake in CRISPR Therapeutics or $35 million.  Any newly created intellectual property from the...
Read More..

BIG IDEA: CRISPR REMAKES THE WORLD

crispr_illo
2016 IS GOING TO BE A BIG YEAR FOR THE GENE EDITING TECHNIQUE The gene-editing technique called CRISPR has the much-hyped potential to revolutionize medicine, deliver designer babies, and end global hunger. Developed from a mechanism found in bacteria, CRISPR allows scientists to cut-and-paste DNA with unprecedented precision. The researchers behind its discovery are favorites to win Nobel prizes in 2016. In the three years since CRISPR was introduced, it has been adopted by thousands of scientists worldwide. Already, they’ve used the technique to create hypermuscular beagles and pigs that can grow human organs for transplant. Innovations that used to take many years to realize can now be made in mere months. “The technology is pretty darn fast,” said Dan...
Read More..