CRISPR, crispr genome editing system

Another miracle: CRISPR is gene-editing pain away

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Scientists say is a step toward a CRISPR gene therapy that could block severe pain caused by diabetes, cancer, or car accidents without the addictive effects of opioids. The street performer was only 10 years old. He put knives through his arms and walked on hot embers. By 14 he was dead. Someone dared him to jump from a roof. He did it, knowing it wouldn’t hurt. The case of the Pakistani boy with a rare genetic disorder was described in 2006. He could feel warmth and cold and the texture of objects. But he never felt pain. Now scientists have paired the discovery with the gene-editing tool CRISPR, in what they say is a step toward a gene therapy that...
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CRISPR enters its first human clinical trials. The gene editor targets cancer, blood disorders and blindness.

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Scientists will soon wield the molecular scissors CRISPR/Cas9 in the human body. Some people with a form of inherited blindness will have the gene editor injected into their eyes, where researchers hope it will snip out a mutation. Since its debut in 2012, CRISPR gene editing has held the promise of curing most of the over 6,000 known genetic diseases. Now it’s being put to the test. In the first spate of clinical trials, scientists are using CRISPR/Cas9 to combat cancer and blood disorders in people. In these tests, researchers remove some of a person’s cells, edit the DNA and then inject the cells back in, now hopefully armed to fight disease. Researchers are also set to see how CRISPR/Cas9...
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CRISPR breakthrough allows scientists to edit multiple genes simultaneously

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Genes and proteins in cells interact in many different ways. Each dot represents a gene; the lines are their interactions. For the first time, the new method uses biotechnology to influence entire gene networks in a single step(Credit: ETH Zurich / Carlo Cosimo Campa) We’ve seen a number of recent improvements to the CRISPR gene editing method, from enhanced precision to novel techniques to block the process. But despite all these innovations, the technique is generally only able to modify one single gene at a time. An incredible new breakthrough from scientists at ETH Zurich has, for the first time, demonstrated a new CRISPR method that can modify dozens of genes simultaneously, allowing for more large-scale cell reprogramming. In a recently published...
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The Future of Medicine Land Within 5 – 10 Years, Crispr Inventor Says

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A pioneer of the Crispr gene-editing technology that’s taken Wall Street by storm says the field is probably five to 10 years away from having an approved therapy for patients. Biochemist Jennifer Doudna, who runs the Doudna Lab at the University of California at Berkeley, says major questions remain about the safety and effectiveness of experimental therapies that aim to disrupt or repair defective genes. But she’s optimistic about their prospects. “Can we today edit the DNA in human cells? Yes. Can we do it accurately? Yes. That’s absolutely being done in many labs around the world now,” Doudna said in an interview on the sidelines of a gene-editing summit at the Cold Spring Harbor Laboratory in New York. “But the challenge is how...
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CRISPR Technology Market to Reach $10.55 Billion by 2027, Reports BIS Research

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According to a new market intelligence report by BIS Research, titled “Global CRISPR Technology Market – Analysis and Forecast, 2018-2027“, the global CRISPR technology market is anticipated to grow to $10.55 billion by 2027. The global CRISPR technology market is projected to grow at a CAGR of 34.46% between the years 2018 and 2027, aided by the remarkable growth in the fields of therapeutic & drug discovery, biological research, and agricultural biotech.  Genetic diseases approximately constitute for 25% of global economic burden for disease. The rising prevalence of several genetic diseases has significantly elevated the requirement for improved gene targeting methods with greater efficiency. The recent advancements in sequencing and genomic technologies has paved pathway for the development of efficient genome editing...
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What is CRISPR gene editing, and how does it work?

You’ve probably read stories about new research using the gene editing technique CRISPR, also called CRISPR/Cas9. The scientific world is captivated by this revolutionary technology, since it is easier, cheaper and more efficient than previous strategies for modifying DNA. The term CRISPR/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated protein 9. The names reflect important features identified during its discovery, but don’t tell us much about how it works, as they were coined before anyone understood what it was. What does CRISPR/Cas9 do? CRISPR/Cas9 is a system found in bacteria and involved in immune defence. Bacteria use CRISPR/Cas9 to cut up the DNA of invading bacterial viruses that might otherwise kill them. Today we’ve adapted this molecular machinery for an entirely different purpose – to change...
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CRISPR gene-editing tested in a person for the first time

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A Chinese group has become the first to inject a person with cells that contain genes edited using the revolutionary CRISPR–Cas9 technique. On 28 October, a team led by oncologist Lu You at Sichuan University in Chengdu delivered the modified cells into a patient with aggressive lung cancer as part of a clinical trial at the West China Hospital, also in Chengdu. Earlier clinical trials using cells edited with a different technique have excited clinicians. The introduction of CRISPR, which is simpler and more efficient than other techniques, will probably accelerate the race to get gene-edited cells into the clinic across the world, says Carl June, who specializes in immunotherapy at the University of Pennsylvania in Philadelphia and led one...
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‘C.R.I.S.P.R.': Jennifer Lopez Sets Futuristic Bio-Terror Drama at NBC

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NBC is reteaming with Jennifer Lopez for a futuristic procedural. The network has handed out a script order to drama C.R.I.S.P.R., which is being produced by the Shades of Blue star, The Hollywood Reporter has learned. C.R.I.S.P.R.— aka ” clustered regularly interspaced short palindromic repeats” — is a procedural thriller set five minutes into the future that explores the next generation of terror: DNA hacking. If the project moves forward, each episode will explore a bio-attack and crime — from a genetic assassination attempt on the president to the framing of an unborn child for murder. The show’s central character is a scientist with the CDC who is paired with an FBI agent. In the same vein of Castle, romance will...
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Cutting Out Cancer: CRISPR Gene Editing Could Make Cancer Mutations Inactive

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A group of researchers from Dresden’s National Center for Tumor Disease (NCT), the Medical Faculty of the Technische Universität (TU) Dresden, and the German Consortium for Translational Cancer Research (DKTK), have found a way to use CRISPR-Cas9 to identify and cut out the particular cancer genes that advance mutations. “Mutations in cancer cells are identified at increasing speed through next generation sequencing, but we mostly do not know, which of these mutations are actually driving the disease and which ones are rather benign,” leading researcher Frank Buchholz said in a journal article. Of the more than 500,000 identified cancer mutations, the researchers were able to confirm that more than 80% can be cleaved using CRISPR-Cas9 scissors. DRIVER AND PASSENGER   National...
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CRISPR used to make a tumour shrink itself

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Scientists have used gene editing to reprogramme a signal that normally promotes tumour growth into one that shrinks it instead. In a study published in Nature Methods, a team from the First Affiliated Hospital of Shenzhen University, China, showed how they could stop the growth of cancer in cells by modifying part of the CRISPR–Cas9 system. When mice carrying these modified genes were tested, scientists found their tumours were far smaller than those seen in control animals. CRISPR-Cas9 is a gene editing platform that is currently being looked at as a means of providing treatments for diseases by targeting cells. Cas9 is an enzyme that cuts a double DNA strand at a point, while CRISPR is a chemical messenger. The...
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