CRISPR, crispr genome editing system - Part 6

Top 10 CRISPR predictions for New Year 2016

CRISPR is the hottest new biotechnology and the top development of 2015 according to Science Magazine. What will the new year of 2016 bring on the CRISPR front? It’s clear there will be more meetings on CRISPR ethics and policy (heck, we are having one right here at UC Davis on May 26), but what else is coming? Below are my top 10 CRISPR predictions for the new year in no particular order. What are your CRISPR predictions? For more on my thinking on CRISPR and the future, also please take a look at my new book, GMO Sapiens and for the extreme case of what could go wrong see my TED talk. The CRISPR predictions. The Noah’s arc of CRISPR-y critters continues...
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Bayer, CRISPR Therapeutics Launch JV to Develop CRISPR/Cas9 Treatments

NEW YORK (GenomeWeb) – Switzerland’s CRISPR Therapeutics and Germany’s Bayer today announced a yet unnamed joint venture to develop ways to deliver CRISPR/Cas9 genome editing in a clinical setting. The deal brings together Bayer’s experience in protein engineering and knowledge of human diseases with CRISPR Therapeutics’ CRISPR/Cas9 intellectual property and genome editing expertise, the firms said in a statement. Under the terms of the agreement, the partners will launch the joint venture to find, develop, and commercialize new therapies for blood disorders, blindness, and congenital heart disease. Bayer will provide at least $300 million over five years for R&D expenses as well as acquire a minority stake in CRISPR Therapeutics or $35 million.  Any newly created intellectual property from the...
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2016 IS GOING TO BE A BIG YEAR FOR THE GENE EDITING TECHNIQUE The gene-editing technique called CRISPR has the much-hyped potential to revolutionize medicine, deliver designer babies, and end global hunger. Developed from a mechanism found in bacteria, CRISPR allows scientists to cut-and-paste DNA with unprecedented precision. The researchers behind its discovery are favorites to win Nobel prizes in 2016. In the three years since CRISPR was introduced, it has been adopted by thousands of scientists worldwide. Already, they’ve used the technique to create hypermuscular beagles and pigs that can grow human organs for transplant. Innovations that used to take many years to realize can now be made in mere months. “The technology is pretty darn fast,” said Dan...
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Genome-editing revolution: My whirlwind year with CRISPR

Jennifer Doudna, a pioneer of the revolutionary genome-editing technology, reflects on how 2015 became the most intense year of her career — and what she’s learnt. Illustration By David Parkins Expand Some 20 months ago, I started having trouble sleeping. It had been almost two years since my colleagues and I had published a paper1 describing how a bacterial system called CRISPR–Cas9 could be used to engineer genomes.I had been astounded at how quickly labs around the world had adopted the technology for applications across biology, from modifying plants to altering butterfly-wing patterns to fine-tuning rat models of human disease. At the same time, I’d avoided thinking too much about the philosophical and ethical ramifications of widely accessible tools for...
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‘We all kind of marvel at how fast this took off’

On a warm September afternoon on the verdant campus of Long Island’s Cold Spring Harbor Laboratory, an elite cadre of scientists gathered to discuss a simple yet incredibly powerful new genetic technology. Jennifer Doudna was dressed casually in a blazer and jeans, with a scarf tossed gently around her neck to compliment a loose bob of blonde hair. Raised in Hilo, Hawaii, she retains a hint of the friendly islander vibe, even though she’s been recently thrust into the scientific spotlight. A biochemist at the University of California, Berkeley, Doudna is widely credited as one of the pioneers of a genetic technology that lets scientists tweak the DNA of practically any living creature. Known as CRISPR/Cas9, the technique has been...
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Bayer and CRISPR Therapeutics AG join Forces to Discover, Develop and Commercialize Potential Cures for Serious Genetic Diseases

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Leverkusen, Germany and Basel, Switzerland, December 21, 2015 – Bayer and CRISPR Therapeutics have entered into an agreement to create a joint venture (JV) to discover, develop and commercialize new breakthrough therapeutics to cure blood disorders, blindness, and congenital heart disease. CRISPR Therapeutics will contribute its proprietary CRISPR-Cas9 gene-editing technology and intellectual property, while Bayer will make available its protein engineering expertise and relevant disease know-how. It is the first long-term strategic partnership of its kind to make a substantial investment in the development of target delivery systems in an effort to bring systemic in vivo CRISPR-Cas9 gene editing technology applications to patients. The JV is the first investment by the newly established Bayer LifeScience Center (BLSC), which operates as...
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Mammoth may be resurrected sooner than you think

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Of all the varied and incredible possibilities presented by the controversial new gene-editing technique known as CRISPR-Cas9, perhaps the most intriguing are efforts to bring animals back from extinction. Candidates for de-extinction, as the process is known, include species like the passenger pigeon (the last one died in captivity in 1914), the dodo (last seen in 1662) and the sea cow (1768, a mere 27 years after it had been discovered by Europeans.) These projects are not pipe dreams. Dr. George Church, a molecular biologist at Harvard University who is working on such projects, estimates that a variation of the first new woolly mammoth (which disappeared some 4,000 years ago) may be born as soon as seven years from now. Like...
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Breakthrough of the Year: CRISPR makes the cut

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By John Travis It was conceived after a yogurt company in 2007 identified an unexpected defense mechanism that its bacteria use to fight off viruses. A birth announcement came in 2012, followed by crucial first steps in 2013 and a massive growth spurt last year. Now, it has matured into a molecular marvel, and much of the world—not just biologists—is taking notice of the genome-editing method CRISPR, Science’s 2015 Breakthrough of the Year. CRISPR has appeared in Breakthrough sections twice before, in 2012 and 2013, each time as a runner-up in combination with other genome-editing techniques. But this is the year it broke away from the pack, revealing its true power in a series of spectacular achievements. Two striking examples—the...
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Heredity Is Nobody’s Fault. Until Now.

We are all unwitting players in a genetic lottery. Take a gene called APOE. It comes in three flavors – APOE2, APOE3 and APOE4. All three are considered normal human genes, but people who were dealt an APOE4 face three to five times the average risk of getting Alzheimer’s disease. Since we inherit a copy of the gene from each parent, a few unlucky people will be stuck with two copies of the APOE4 version and face an even higher risk. To put it in perspective, by age 75 about 3 percent of people get Alzheimer’s. For those with double APOE4, that rises to about 30 percent. Now a technology called gene editing could allow us to rig the game....
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The Genetic Revolution Could Curb World Hunger And Pesticide Use

Credit: Roberto Machado Noa/Getty Images The genetic revolution is coming to your dinner plate. Over the past year or so, researchers around the world have begun using a new gene-editing technique that has the potential to help stop world hunger, end the use of pesticides and improve our health. The technique, known as CRISPR-Cas9, allows scientists to change, delete or replace DNA more easily than ever before. Theoretically, this could allow farmers to grow crops that are bigger, tougher and more nutritious. Hypoallergenic peanuts? Wheat that is invulnerable to mildew? Drought-resistant corn or healthier tomatoes? CRISPR could make all these things not only possible, but quick and cheap to produce. As Newsweek pointed out in a feature story published earlier...
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